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The 1918 flu pandemic (January 1918 – December 1920) was an unusually deadly influenza pandemic, the first of the two pandemics involving H1N1 influenza virus.〔(''Institut Pasteur. La Grippe Espagnole de 1918'' (Powerpoint presentation in French) ).〕 It infected 500 million people across the world, including remote Pacific islands and the Arctic, and resulted in the deaths of 50 to 100 million (three to five percent of the world's population〔(【引用サイトリンク】url=https://www.census.gov/population/international/data/worldpop/table_history.php )〕), making it one of the deadliest natural disasters in human history. Most influenza outbreaks disproportionately kill juvenile, elderly, or already weakened patients; in contrast, the 1918 pandemic predominantly killed previously healthy young adults. Modern research, using virus taken from the bodies of frozen victims, has concluded that the virus kills through a cytokine storm (overreaction of the body's immune system). The strong immune reactions of young adults ravaged the body, whereas the weaker immune systems of children and middle-aged adults resulted in fewer deaths among those groups. Historical and epidemiological data are inadequate to identify the pandemic's geographic origin. It was implicated in the outbreak of encephalitis lethargica in the 1920s. To maintain morale, wartime censors minimized early reports of illness and mortality in Germany, Britain, France, and the United States;〔 〕 but papers were free to report the epidemic's effects in neutral Spain (such as the grave illness of King Alfonso XIII), creating a false impression of Spain as especially hard hit—thus the pandemic's nickname Spanish flu. In Spain, a different nickname was adopted, the Naples Soldier, which came from a musical operetta (zarzuela) titled ''La canción del olvido'' (''The Song of Forgetting''), which premiered in Madrid during the first epidemic wave. Federico Romero, one of the librettists, quipped that the play's most popular musical number, ''Naples Soldier'', was as catchy as the flu. ==History== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「1918 flu pandemic」の詳細全文を読む スポンサード リンク
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